COMPUTATIONAL ANALYSIS OF CODE-MULTIPLEXED COULTER SENSOR SIGNALS

Nowadays, lab-on-a-chip (LoC) technology has been applied in a variety of applications because of its capability to perform accurate microscale manipulations of cells for point-of-care diagnostics. On the other hand, such a result is not readily available from an LoC device and typically still requires a post-inspection of the chip using traditional laboratory equipment such as a microscope, negating the advantages of the LoC technology. To solve this dilemma, my doctoral research mainly focuses on developing portable and disposable biosensors for interfacing with and digitizing the information from an LoC system. Our sensor platform, integrated with multiple microfluidic impedance sensors, electrically monitors and tracks manipulated cells on an LoC device. The sensor platform compresses information from each sensor into a 1-dimensional electrical waveform, and therefore, further signal processing is required to recover the readout of each sensor and extract information of detected cells. Furthermore, with the capability of the sensor platform, we have introduced integrated microfluidic cytometers to characterize properties of cells such as cell surface expression and mechanical properties.Ph.D

Early-Stage Estimated Value of Blend Sign on the Prognosis of Patients with Intracerebral Hemorrhage

Background and Purpose. This study aimed to explore the relationship between blend sign and prognosis of patients with intracerebral hemorrhage (ICH). Methods. Between January 2014 and December 2016, the results of cranial computed tomography imaging within 24 h after the onset of symptoms from 275 patients with ICH were retrospectively analyzed. The patients with or without blend sign were compared to observe and analyze the difference in coagulation function abnormality, rebleeding, mortality, and bad prognosis rates in the early stages. Results. Of the 275 patients with ICH, 47 patients had Blend Sign I (17.09%) and 17 patients had Blend Sign II (6.18%). The coagulation function abnormality rate had no statistical difference among Blend Sign I, Blend Sign II, and conventional groups (P>0.05). In the Blend Sign I group, the rebleeding rate was 4.26%, bad prognosis rate was 25.53%, and mortality rate was 6.38%, which were not statistically significantly different compared with those in the conventional group (P>0.05). The rebleeding rate in the Blend Sign II group was 47.06%, bad prognosis rate was 82.35%, and mortality rate was 47.06%, which were statistically significantly different compared with those in the conventional and Blend Sign I groups (P<0.05). Conclusions. For the patients associated with Blend Sign I, the prognosis was equivalent to that in the conventional group, with no statistically significant difference. The rebleeding, bad prognosis, and mortality rates were higher in the Blend Sign II group than in the conventional group and deserved more attention

Optical Turbulence Characteristics in the Upper Troposphere&ndash;Lower Stratosphere over the Lhasa within the Asian Summer Monsoon Anticyclone

The high elevation, complex topography, and unique atmospheric circulations of the Tibetan Plateau (TP) make its optical turbulence characteristics different from those in low-elevation regions. In this study, the characteristics of the atmospheric refractive index structure constant (Cn2) profiles in the Lhasa area at different strength states of the Asian summer monsoon anticyclone (ASMA) are analyzed based on precious in situ sounding data measured over the Lhasa in August 2018. Cn2 in the upper troposphere&ndash;lower stratosphere fluctuates significantly within a few days during the ASMA, particularly in the upper troposphere. The effect of the ASMA on Cn2 varies among the upper troposphere, tropopause, and lower stratosphere. The stronger and closer the ASMA is to Lhasa, the more pronounced is the &ldquo;upper highs and lower lows&rdquo; pressure field structure, which is beneficial for decreasing the potential temperature lapse rate. The decrease in static stability is an important condition for developing optical turbulence, elevating the tropopause height, and reducing the tropopause temperature. However, if strong high-pressure activity occurs at the lower pressure layer, such as at 500 hPa, an &ldquo;upper highs and lower highs&rdquo; pressure field structure forms over the Lhasa, increasing the potential temperature lapse rate and suppressing the convective intensity. Being almost unaffected by low-level atmospheric high-pressure activities, the ASMA, as the main influencing factor, mainly inhibits Cn2 in the tropopause and lower stratosphere. The variations of turbulence intensity in UTLS caused by ASMA activities also have a great influence on astronomical parameters, which will have certain guiding significance for astronomical site testing and observations